Archives → 2021 → V. 61. № 5 → pp. 515-523
Article
Leukemia inhibitory factor and cellular turnover in various types of pulmonary fibrosis in plutonium production workers
Sychugov G.V.1, Kazachkov E.L.1, Osovets S.V.2, Grigoryeva E.S.2, Sychugov A.G.1, Azizova T.V.2
1South Ural State Medical University affiliated to the Ministry of Health of the Russian Federation, Chelyabinsk, Russia 2Southern Urals Biophysics Institute affiliated to the Russian Federal Medical Biological Agency, Ozyorsk, Russia
Abstract
The present study was aimed to identify types of morphological and functional interactions between the leukemia inhibiting factor and the complex of cellular turnover regulators in pulmonary structures altered due to various types of fibrosis in individuals occupationally exposed to ionizing radiation. Morphological features of pulmonary fibrosis were examined in biological specimens of lung tissues collected during autopsies (pa-raffin-embedded tissue sections) from 56 workers who had been diagnosed with plutonium-induced pulmonary fibrosis (PuPF) when they had been alive, 34 workers who had been diagnosed with pulmonary fibrosis of a different origin (as an outcome of chronic inflammatory pulmonary diseases) (non-PuPF) and 35 wor-kers without any lung disease (controls). A thorough morphological examination of lung tissue specimens for all cases was performed using ummunochistochemistry (IHC). Quantification of the IHC observations was carried out using «Morphology 5.1» computer image analysis. Markers of cell proliferation, apoptosis and leukemia inhibitor factor were demonstrated to be associated with the cumulative lung absorbed dose of internal α-radiation.
Keywords
Apoptosis, proliferation, Leukemia inhibitory factor, α-radiation, ionizing radiation, Mayak PA
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