Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2021 → V. 61. № 5 → pp. 480-491

Article

The effect of iodine and selenium preparations on the course and outcome of acute radiation damage

R. O. Vasiliev¹, I. S. Drachev², N. Yu. Yugatova¹, E. I. Troshin¹, V. A. Myasnikov², A. N. Grebenyuk³

¹Saint Petersburg State University of Veterinary Medicine, Saint Petersburg, Russia ²State Scientific Research Test Institute of the military medicine, Saint Petersburg, Russia ³Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia

Abstract

In experiments on mice, the study of the radioprotective and therapeutic effectiveness of the combined use of selenium-containing feed additive DAFS-25к and iodine-containing drug Monklavit-1 was carried out. It was shown that intragastric administration of an oil solution of DAFS-25к 3 hours before the total external single exposure to ¹³⁷Cs γ-radiation, at a dose of 6.0 Gy, at a dose rate of 0.99 Gy/min followed by intragastric administration of an aqueous solution of Monclavit-1 after 12 hours increases the survival rate of irradiated animals to 67% against 17% in the control. At the same time, the frequency of gastrointestinal syndrome in mice with the combined use of DAFS-25к in the dose range before irradiation and Monclavit-1 after irradiation decreased to 50 and 42% against 100% in the control of irradiation. Subsidies of iodine and selenium in the composition of DAFS-25к and Monklavit-1 drugs favorably affect the absolute content of leukocytes and platelets in the peripheral blood of irradiated mice, reducing the severity of leukocytopenia and thrombocytopenia during the «height» of acute radiation damage and accelerate the recovery of the population of these shaped elements. It is assumed that possible mechanisms of radioprotective effectiveness are the antioxidant activity of selenium compounds in DAFS-25к, normalization of thyroid function and relief of gastrointestinal syndrome through the expressed antimicrobial activity of Monclavit-1.

Keywords

Irradiation, acute radiation syndrome, DAFS-25k, monclavit-1, Iodophore, gastrointestinal syndrome, radioprotective effect