Archives2021V. 61. №2.pp. 144–150


Cytostatic and Radiomodifying Effects of D-Glucosamine on Human Cells in Culture

N. Ya. Giliano, M. M. Dubotolova, L. A. Noskin, L. V. Konevega, S. I. Stepanov, and F. M. Ibatullin

Petersburg Institute of Nuclear Physics B. P. Konstantinova, Research Center “Kurchatov Institute”, Gatchina, Russia


The role of the cytostatic factor in the cytotoxic effect of γ-quantum 60Co before and after treatment of cells with a glycolysis inhibitor d-glucosamine was studied on 3 human cell lines. It was shown that treatment of cells with d-glucosamine hydrochloride led to the accumulation of cells in the G1 phase of the cell cycle. The pre-radiation treatment of cells with d-glucosamine leads to a significant (more than 2-fold) increase in the proportion of apoptotically dying tumor cells (lines HeLa G 63, Hep G2), compared with separate exposure, which is not observed for non-tumor cells (ECV 304). d-glucosamine induced selectively directed radiosensitization of tumor cells. A synergistic effect was recorded 48 hours after irradiation. d-glucosamine is believed to inhibit ATP-dependent post-radiation repair processes.


cell cycle, γ-quantum 60Со, apoptosis, d-glucosamine, cytometry, human cell culture

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