Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2020 → V. 60. №3. → pp. 291–297

Article

Investigation of Radioprotective Efficiency of the Condensation Products of Thiol-containing Hydrazides with Mono- and Disaccharides

I. V. Lagoda^a, E. А. Yakunchikova^a, I. S. Drachyov^a, А. N. Grebenyuk^ab, A. A. Martynenkov^c, L. Yu. Kuleshova^d, M. A. Kopanitsa^d, and A. Yu. Ershov^c

^aState Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, Saint Petersburg, Russia ^bPavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia ^cInstitute of Macromolecular Compounds of the Russian Academy of Sciences, Saint Petersburg, Russia ^dRyazan State Medical University named after academician I.P. Pavlov, Ryazan, Russia

Abstract

The radioprotective activity of the sugar-containing compounds (aldose mercaptoacylhydrazones) based on condensation products of thioglycolic (TGH) and thiosalicylic (TSH) acids hydrazides with the series of natural aldoses: В-glucose (Glc), В-galactose (Gal), D-lactose (Lac) and D-maltose (Mal), was experimentally
studied in mice. It was shown that application of Glc-TGH and Mal-TSH improved survival of lethally irradiated animals by 25 and 40% upon administration 1 and 24 h before irradiation respectively. It is supposed that defense of the animals’ stem hemopoietic cells plays the critical role in the drugs’ antiradiation activity.

Keywords

ionizing radiation, thiol-containing mono- and disaccharides, precious metals’ nanoparticles glycoligands, radioprotective action