Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2020 → V. 60. №3. → pp. 279–290

Article

Difficulties in Radiation Counter Measure Preparations Development in Russia in Crysis Period: Actual Approaches Searching

L. M. Rozhdestvensky

SRC – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia

Abstract

It is considered the process of radiation countermeasures searching and founding in close connection with leading radiobiological conceptions and drug classifications in different periods. The great number of antiradiation drugs is divided on 2 main groups: radioprotectors/oxidomodulators and radiomodulators/cytomodulators.
The base of a such division is their end action in 2 main stages of radiobiological process: radiochemical and cellular death accordingly. Searching new anti-radiation drugs seems unpromising after the previous screening. It is indispensably to stimulate the preparedness of some anti-radiation drugs investigated in experiments. For example to certificate a nonlicension preparation by means of some pharmacological approaches: combination of two or more preparations to increase anti-radiation effect and/or to decrease discomfort side effect. The most actual directions seem to be anti-radiation drugs searching in the field of cosmic radiation for astronauts and relative to remote radiation effects at different radiation exposure scenarios, even for inlethal exposures. It is considered the last direction on the example of experiment results concerning a model of prolonged mice exposure to gamma-radiation with small dose rate. There are presented for prospect such investigation directions as hibernation at severe radiation damages and radiation hormesis. In conclusion there is a lot of not solved issues concerning drug provision of radiation safety in different radiation incidents.

Keywords

classification of anti-radiation agents, anti-radiation formulation, markers of increased radioresistance, post-radiation hibernation, radiation hormesis