Archives → 2020 → V. 60. №3. → pp. 229–238
Article
Radiation-induced Inter-organism Bystander Effects. Some Aspects of the Transmission
V. V. Petushkova I. I. Pelevina, I. N. Kogarko, Е. А. Neyfakh, B. S. Kogarko, and O. V. Ktitorova
N.N. Semyonov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia
Abstract
The study makes a contribution to our Group integrated project for the research of radiation-induced nontargeted effects. The radiation-induced inter-organism bystander effect is one of the least studied in terms of manifestations and mechanisms phenomena. The international practice of the laboratory works for inter-organism bystander effects was started in fish and other aqua cultures. In our experiment mice where irradiated (exposed to a single 3 Gy γ-ray dose), and then contacted with non-irradiated companions for three months. Our work using female outbred mice shows the changes similar to the radiation –induced pathology in organisms of non-irradiated bystander mice. The changes in behavioral reactions, significant trends towards a redaction of spleen weight, severe alopecia and other signs of abnormalities similar to radiation-induced were registrated. Discussions of possible mechanisms of the phenomena refer both to the theory of radio toxicology
by A. Kuzin, and to testing of various hypotheses in new research practice of C. Mothersill. The aim of the work is to draw attention to the need of further studies of radiation-induced inter-organism level bystander effects.
Keywords
radiation-induced non-targeted effects, outbred female mice, radiation-induced inter-organism bystander effects, radio toxicology, lipid peroxides, biophotons
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