Archives → 2019 → Vol. 59, No. 2 → pp. 170-176
Article
Perspectives for Cytokines and Cytokine Synthesis Inducers as Radioprotectors
Simbirtsev A.S., Ketlinsky S.A.
State Research Institute of Highly Pure Biopreparations, Federal Medico-Biological Agency, St. Petersburg, Russia
Abstract
Several radioprotective and antitoxic preparations have been developed using modern biotechnology methods. Among them are recombinant cytokines (colony-stimulating factors and interleukin-1) and bacterial-derived immunomodulators stimulating innate immunity and endogenous cytokine synthesis (flagellin). Clinical trials show that recombinant human interleukin-1 beta decreases leucopenia duration in the patients receiving high-dose anticancer radio- and chemotherapy, thus leading to hematopoietic reconstitution. Complex medicines based on the combination of hematopoietic cytokines (IL-1) and free oxygen blockers, for instance superoxide dismutase, could be used in order to increase reconstitution effectiveness after radiation exposure.
Keywords
Irradiation, radioprotection, cytokines, interleukin-1, flagellin, superoxide dismutase
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