Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2019 → Vol. 59, No. 1 → pp. 103-112

Article

Mineral Density of Bone Tissue as a Deposit Factor for ⁹⁰Sr: Experimental Data

Starichenko V.I.

Institute of Plant and Animal Ecology, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia

Abstract

The study of the kinetics of bone-seeking radionuclides (in particular ⁹⁰Sr) depending on the functional state of bone tissue is associated with the existing threat of radiation incidents and increasing use of medical radionuclide preparations for medical and diagnostic purposes. The bone-seeking radionuclides, accumulating in the skeleton and remaining there for a long time, are sources of chronic internal radiation. The magnitude of their incorporation (resulting in accumulation and elimination processes) depends on a variety of endo- and exogenous factors. The most important endogenous factor is bone mineral density (BMD) – one of its main characteristics. In this paper, we study the dependence of the ⁹⁰Sr accumulation on BMD after a single administration of radionuclide. The study was carried out in a laboratory experiment on mature CBA mice of different ages developing under standard vivarium conditions and under the influence of factors that modulate the growth processes in the body. An inverse correlation (r = –0.77, p < 0.0001) is shown between the accumulation of ⁹⁰Sr and the degree of mineralization of the skeleton. A comparison is made with the data previously obtained by the authors in the natural environment on two species of murine rodents living in a zone of the Eastern Ural Radioactive Trace under conditions of chronic intake of ⁹⁰Sr.

Keywords

⁹⁰Sr, skeleton, modifying factors of development, NEA mice, bone mineral density (BMD)