Archives → 2018 → Vol. 58, No. 6 → pp. 619-623
Article
Potentiative Effect of Normobaric Hyperoxia on Indralin Radiation Protective Action in Hematopoietic Tissues
Vasin M.V.1, Ushakov I.B.2,3, Koroleva L.V.2, Antipov V.V.2
1 Russian Medical Academy of Continuous Professional Education of Ministry of Health Care, Moscow, Russia. 2Burnazian Federal Medical Biophysical Сentre of Federal Biomedical Agency of Russia, St.-Petersburg, Russia. 3 Nikiforov All-Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St.-Petersburg, Russia.
Abstract
Modification effect of normobaric hyperoxia to radiation protective action of radioprotector Indralin (B-190) was investigated in the experiments on mice. The animals were exposed to γ-quanta 60Со at the doses of 6 and 9 Gy and the dose rate of 30–45 сGy/min. Medical 100% oxygen was blown through a chamber with mice before, during and after irradiation with a period of 20 min. Short-term hyperoxia did not influence the hematopoietic tissue radiosensitivity during irradiation. Hyperoxia after irradiation mitigated the hematopoietic syndrome of acute radiation disease. Radioprotector Indralin at a dose close to ED50 exerted radiation protective action on hematopoietic system as well as hematopoietic stem cells, which induced bone marrow repair by the 15th day after irradiation at a dose of 6 Gy, whereas this process in the control radiation group took place by the 45th day of the disease. Hyperoxia during and after irradiation potentiated indralin radiation protective effect on hematopoietic stem cells that caused earlier post-radiation repair of hematopoietic tissues.
Keywords
γ-radiation, normobaric hyperoxia, indralin, CFU, post-radiation hematopoietic repair
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