Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2023 → Vol. 63, № 3 → pp. 255–260

Article

Metabolic Correction of Cerebral Radiation Syndrome in Small and Large Animals

M. V. Vasin¹, L. A. Ilyin², Yu. N. Chernov³, I. B. Ushakov²

¹Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russia ²Burnazyan Federal Medical Biophysical Center of FMBA of Russia, Moscow, Russia ³Burdenko Voronezh State Medical University, Voronezh, Russia

Abstract

In experiments on mice, rats, guinea pigs and dogs, the effectiveness of metabolic correction of cerebral radiation syndrome with nicotinic and succinic acids and Esseentiale was evaluated. The animals were totally exposed to 5–8 and 16–20 MeV pulsed electron flux at doses of 85–110 or 500–570 Gy or to gamma irradiation at a dose of 100 Gy. The frequency and time of ataxia and convulsions, as well as the dynamics of animal death after radiation were recorded. Nicotinic and succinic acids (500 mg/kg each) and Esseenciale (20 mg/kg by nicotinamide) reduced the frequency and delayed the onset of ataxia and seizures equally in both small laboratory animals and dogs. In experiments on rats after exposure at a dose of 100 Gy under the influence of radiation and Essentiale, there was no significant change in animal cognitive function according to the decision-making test at the first presentation of a new deposit.

Keywords

Cerebral radiation syndrome, ataxia, convulsions, nicotinic acid, succinic acid, nicotinamide, dogs, small laboratory animals