Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2022 → Vol. 62, № 5 → pp. 555-558

Article

Quantitative Approach to the Assessment of Yeast Cell Genetic Instability

Petin V.G.¹, Rubanovich A.V.²

¹A. Tsyb Medical Radiological Research Centrе – branch of the National Medical Research Radiology Centrе of the Ministry of Health of the Russian Federation, Obninsk, Russia ²N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

Abstract

This work is devoted to a review of published results on the genetic instability of yeast cells, quantified by the delay in the formation of colonies by cells surviving after irradiation. It was shown that genetic instability is determined by cell ploidy regardless of their radiosensitivity and cell ability to recover radiation damage. It has been shown that the RBE of ²³⁹Pu α-particles is practically the same for both cell survival and genetic instability of diploid and haploid yeast cells.

Keywords

Genetic instability, ionizing radiation, survival, yeast cells, haploid and diploid cells