Archives → 2022 → Vol. 62, № 5 → pp. 502-512
Article
The Effect of Multivitamins on the Content of Glutathione and Lipid Antioxidants in Blood Plasma in People Exposed to Low-intensity Radiation
Ivanenko G.F.
N.M. Emanuel Institute of Biochemical Physics, Russian Academie of Sciences, Moscow, Russia
Abstract
A study was made of the effect of a multivitamin complex on the state of the redox system of glutathione (reduced form of GSH, oxidized form of GSSG) and lipid antioxidants (vitamins E and A) in the blood plasma of Chernobyl disaster liquidators who worked at different times in the accident zone, and children exposed to extreme environmental factors as a result of this radiation incident. Oral therapy with a combination drug, the action of which is due to the effects of vitamins, macro- and microelements included in its composition, leads to the normalization of the antioxidant system in the blood plasma in exposed individuals of the examined groups in the early stages (1–5 months) after its use. This protective reaction has a limitation, so after 10 months the effectiveness of therapy in the liquidators of the accident decreases due to the consumption of antioxidants in the blood plasma, as evidenced by the values of the considered indicators corresponding to the levels of irradiated control (before taking multivitamins). In a group of children living in a territory contaminated with radionuclides, an increase in GSSG and vitamin A in blood plasma was found 10 months after vitamin therapy. The results of a comprehensive assessment of individual deviations of biochemical parameters from the norm after multivitamin therapy in people exposed to low-intensity radiation indicate a radiogenic etiology of the identified pathologies. The use of vitamin preparations requires some caution and a deeper study of the mechanisms for implementing their therapeutic effects, aimed at reducing possible health risks associated with exposure to ionizing radiation in low doses.
Keywords
Children, liquidators, blood plasma, ionizing radiation, vitamins, glutathione
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