Archives → 2022 → Vol. 62, № 5 → pp. 484-494
Article
The Effect of Ionizing Radiation on the Development of Tumors of the Central Nervous System
Moseeva M.B.
South Ural Institute of Biophysics of FMBA of Russia, Ozyersk, Russia
Abstract
Primary tumors (PT) of the central nervous system (CNS) are relatively rare diseases as compared with other tumors in adults, while they take the second place in the cancer mortality among persons younger 19 years old. In the developed countries there was an increase in CNS PT incidence during 1970s to early 1990s, which was presumably due to making computerized tomography scanning and magnetic resonance imaging accessible, achievements in non-malignant CNS tumor registration and improvements in clinical practice. To date despite the fact that the effects of different factors on the CNS PT development were analyzed in a number of studies, epidemiologists have only come to an agreement for several of them. Findings from the studies indicate that ionizing radiation is one of a few agreed risk factors for CNS PT and the only modifiable factor. Information on quantitative estimates of radiogenic risk for different types of CNS PT is extremely scarce. This review shows that increased risk of CNS PT is primarily associated with exposure to high radiation doses (therapeutic, diagnostic, and bombing) as well as childhood radiation exposure. At present additional studies on quantitative estimates of radiogenic risk for CNS PT after exposure to low radiation doses and among adults are needed.
Keywords
Central nervous system, primary tumors, radiogenic risk, mortality, incidence
Current Issue
FAQs
The length of a manuscript should be justified by its content.
The average period from submission to first decision in last year was 30 days, and that from first decision to acceptance was 40 days. The rejection rate for submitted manuscripts in last year was 15%.