Archives → 2022 → Vol. 62, № 1 → pp. 55-69
Article
Long-Term Neurobiological Effects of Combined Exposure to Anti-Orthostatic Hanging and Ionizing Radiation
K. B. Lebedeva-Georgievskaya1, A. A. Perevezentsev1, O. S. Kuznetsova1, V. S. Kudrin1,2, A. A. Masanova1, A. S. Shtemberg1
1State Scientific Center of the Russian Federation – Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia 2V.V. Zakusov Research Institute of Pharmacology Russian Academy of Medical Sciences, Moscow, Russia
Abstract
A study of the long-term consequences of the combined effect of synchronous quasi-chronic γ-irradiation and anti-orthostatic suspension (AOS) with further irradiation of the head of rats with carbon 12C ions, taking into account the typological characteristics of higher nervous activity (HNA) of experimental animals, was carried out. It is shown that within 6 months the integrative effects of the studied effects are quite successfully leveled. At the same time, significant differences related to the typological characteristics of animals persist in the long term. The study of the spectral and amplitude-frequency characteristics of the EEG of rats after these effects was carried out. Significant differences in the average amplitudes and frequencies of the EEG were revealed in animals with different typological characteristics of the HNA. The change of the dominant rhythm in animals subjected to experimental influences is shown. Thus, in control animals, the τ-rhythm is dominant, while in irradiated animals, the δ-rhythm dominates. The most important result was the registered significant changes in the electrophysiological activity of the rat brain even six months after irradiation. A significant frequency shift in the area of all rhythms indicates a long-term violation of the electrophysiological activity of the brain. The results of neurochemical studies revealed significant differences in the metabolism of monoamines in key brain structures of animals with different typological characteristics of HNA, combined with their manifestation at the integrative level (in animal behavior).
Keywords
combined exposure, γ-irradiation, carbon ions, long-term effects, EEG, animal behavior, monoamine balance in the brain
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