Archives → 2021 → V. 61. № 6 → pp. 625-631
Article
Evaluation of Radiomodificator Betaleukine Influence on Exposed Lewis Carcinoma Growth in Mice
L. M. Rozhdestvensky1, A. A. Lipengolts1,2, N. I. Lisina1, K. Yu. Romanova1
1A.I. Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency of Russia, Moscow, Russia 2N.N. Blochin National Medical Research Oncology Center of Russia Health Ministry, Moscow, Russia
Abstract
There were conducted 4 experiments on mice C57Bl/6 with transplanted Lewis carcinoma consisted in administration radiomodificator betaleukine (recombinant human interleukine-1β) twice (24 h before and immediately after local 20 Gy exposure). Criteria of betaleukine influence on carcinoma growth were duration of growth retardation after exposure and growth rate after restoring the last one in comparison with intact and exposed controles. Betaleukine administration didn’t influence nor growth retardation nor growth rate. But in one from 4 experiment series it was noted growth retardation increasing and growth rate decreasing (the former was valid, the last was just a trend). In the same experiment the carcinoma growth rate in intact controle was the least one among all others. It is concluded that model of transplantation tumor in mice may serve for radiation countermeasure agents preliminary evaluation regarding their use in medical praxis of ca-ner radiation and chemotherapy.
Keywords
Transfused Lewis carcinoma in mice, local radiation of the tumor, Betaleukin, tumor growth
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