Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2021 → V. 61. № 6 → pp. 615-624

Article

Adaptation Plasticity of Brain and Liver Creatine Kinases of Rats Exposed to Total X-Ray Irradiation

L. S. Nersesova, M. S. Petrosyan, S. S. Gasparyan, M. G. Gazaryants, J. I. Akopian

Institute of Molecular Biology, National Academie of Sciences of RA, Yerevan, Armenia

Abstract

The body’s adaptation to the effect of any factor is associated with energy expense. The creatine-creatine kinase (Cr–CK) system plays a crucial role in maintaining the cell energy and Ca-homeostasis, as well as in preserving the structural and functional stability of the mitochondria. Thus, it facilitates the adaptation of the cellular energy metabolism to the potential impacts of the stress factors. The comparative assessment of the adaptive capacities of the rat brain and liver CK exposed to single-dose total irradiation, as well as the influence of Cr as a dietary supplement on the respective changes, based on the analysis of post-radiation alte-rations of the CK, as well as alanine and aspartate aminotransferases (AST and ALT) activity level dynamics cross-comparatively studied has revealed the following: the Cr-CK system of the rat brain and liver has a significant adaptive native plasticity, which is stimulated by Cr. The dynamics of post-radiation alterations in the activity levels of the liver CK and AST of the irradiated rats is of similar character, which is indicative of some joint engagement of these enzymes in the post-radiation adaptive reprogramming of the mitochondria energy metabolism. The adaptive plasticity of the CK is tissue-specific and relates to the intensity of the energy metabolism and the amount of enzyme in the tissue. The fluctuating nature of post-radiation changes in the brain and liver CK activity levels in time may indicate some delayed effects of X-ray radiation, as well as activation of various post-radiation enzyme adaptation mechanisms.

Keywords

X-ray irradiation, adaptation, Creatine kinase activity, creatine, energy metabolism, brain, liver, rats