Archives → 2021 → V. 61. № 6 → pp. 563-606
Article
Causal Criteria in Medical and Biological Disciplines: History, Essence and Radiation Aspect. Report 3, Part 2: Last Four Hill’s Criteria: Use and Limitations
A. N. Koterov
A.I. Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
Abstract
Report 3 is devoted to the history, nature and limitations of the epidemiological criteria of causation ( «Hill’s criteria»). Based on material from the original publications of leading researchers of causality (A.B. Hill., M.W. Susser, K. Rothman and others; 1950s – 2019), from dozens of modern textbooks on epidemiology and carcinogenesis, from documents of international and internationally recognized organizations (UNSCEAR, BEIR, USEPA, IARC, etc.), as well as from many other sources, in part 2 of the report, the last four Hill criteria are considered: biological plausibility, coherence with current facts and theoretical knowledge, experimental and analogy. The theoretical and practical aspects for each criterion are presented: history of appearance, terminology, philosophical and epidemiological essence, applicability in various disciplines and limitations. Factual examples are provided for each of the criteria, including data from Radiation Epidemiology and Radiation Medicine.
Keywords
Criteria for causality, the Hill criteria, biological plausibility, coherence, experimental and analogy
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