Archives → 2021 → V. 61. № 3 → pp. 227-233
Article
Association Between Hypermethylation of Gene Promoters and Cytogenetic Disturbances in Humans Exposed to Radiation as a Result of the Chernobyl Accident
N. S. Kuzmina, N. Sh. Lapteva, A. V. Rubanovich
N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
Abstract
The estimation of association between hypermethylation of gene promoters (RASSF1A, p16/INK4A, p14/ARF cell cycle genes and GSTP1 involved in xenobiotic detoxification) in blood leukocytes and cytogenetic disturbances in humans exposed to radiation as a result of the Chernobyl accident (98 subjects: the accident liquidators liquidators – 76 subjects, adult residents of the territories with radionuclide contamination, 135–688 kBq/m2 – 22 subjects) was carried out. The results of multiple regression analysis ( «frequency of aberrations ~ age + number of hypermethylated genes») demonstrate the correlation of the total level of chromosomal type aberrations with the considered epigenetic disturbances (β = 0.256; p = 0.011), but not with age (β = –0.138; p = 0.165). The frequency of these cytogenetic disorders increases with the number of methylated loci. Thus, a positive association between the damages of genome induced by radiation exposure (the range of small and medium doses) long time ago, and hypermethylation of CpG-islands in promoters of genes involved in the basic protective functions of cells was revealed.
Keywords
Hypermethylation, Gene promoter, CpG island, blood leukocytes, human body, chromosome aberrations, radiation exposure
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