Archives → 2018 → Vol. 58, No. 4 → pp. 382–388
Article
To the Question of the Character of Early Abnormalities of Neuroendocrine Exchange in Animals Irradiated at High Doses
Drachev I.S.1, Legeza V.I.2, Seleznev A.B.1, and Grebenyuk A.N.2
1 State Scientific Research Test Institute of the military medicine, St. Petersburg, Russia
2 Military Medical Academy, St. Petersburg, Russia
Abstract
The dynamics of changes in metabolism of some bioregulators (biogenic amines, opioid peptides, prostaglandins) in various organs and tissues of rats and dogs was studied in the early periods following a whole-body short-term γ-irradiation at doses of 50–100 Gy. It has been shown that the rate of dopamine and serotonin turnover, as well as the encephalin content in subcortical-stem structures of the brain, increases in rats in the first minutes or hours following the radiation exposure. The content of β-endorphin and histamine increases in blood plasma of irradiated rats and dogs. The number of enterochromaffin cells decreases in crypts and villus of the mucous membrane in small intestine of irradiated rats while in dogs, the degranulation of mast cells occurs in the area postrema of medulla oblongata. In dogs, irradiation is accompanied by a short-term increase in the content of prostaglandins in blood plasma, while in rats – by a decrease in the le el of neuromodulators in the tissues of small and large intestine. The findings are being discussed now in connection with a possible role of the revealed disorders in the pathogenesis of a primary reaction to irradiation.
Keywords
Ionizing radiation, irradiation, experimental models, dofamine, serotonin, histamine, opioid peptides, prostaglandins, enterochromaffin cells, mast cells
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