Archives → 2018 → Vol. 58, No. 3 → pp. 262-271
Article
Risk of Acute Myocardial Infarction in People Occupationally Exposed to Irradiation
Semenova Yu.V.1 2, Karpov A.B.1 2, Takhauov R.M.1 3, Maximov D.E.1 3, Kalinkin D.E.1 3, Zvereva N.P.2, Trivogenko A.B.2, Zerenkov A.G.1, Efimova E.V.4
1 Seversk Biophysical Research Center, Seversk, Russia
2 Seversk Clinical Hospital of the Siberian Federal Research and Clinical Center, Seversk, Russia
3 Siberian State Medical University, Tomsk, Russsia
4 Cardiology Research Institute, T, Tomsk, Russia
Abstract
The results of the prospective epidemiological study evaluating the risk of developing acute myocardial infarction (AMI) in people who occupationally exposed to irradiation, taking into account the effect of non-radiation risk factors for the development of cardiovascular diseases, are presented. The observation period is 1998-2013. The studied cohort included workers from the Siberian Group of Chemical Enterprises (SGCE) employed from 01.01.1950 to 31.12.1994. The total number of the cohort is 34.146; among them 23.659 are men and 10.487 are women. 1.252 people (321 women and 931 men) had the diagnosis of «acute myocardial infarction» (codes according to ICD-X I 21.0-I 21.4). 6.334 men and 2.056 women of the entire cohort were under individual dosimetric control for external exposure. Among the SGCE workers, who had suffered an acute myocardial infarction, 630 people (529 men and 101 women) had external and internal dosimetry data. An increase in the relative risk of AMI morbidity by 7-17% in male SGCE personnel, who had contact with ionizing radiation sources in the workplace, was found in comparison with non-irradiated workers. Combined exposure is accompanied by an increase in age-specific morbidity rates of AMI among the people of working age (in the age group 35-39 years and 50-54 years) and among men of the older age group (80-84 years). Regression analysis made it possible to confirm the presence of a dose-effect relationship for the incidence of AMI in the observed cohort in the studied dose range.
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