Archives → 2018 → Vol. 58, No. 3 → pp. 238-244
Article
The Influence of Tumor Cells on Peripheral Blood Lymphocytes (in vitro and in vivo Investigations)
Antoshchina M.M.1 2, Aleshenko A.V.2 3, Vorobyeva N. Yu.2, Biriukov V.A.1, Karyakin O.B.1, Ktitorova O.B.2, Minaeva N.G.1, Pleshakova R.I.2, Ovsiannyakova N.S.1 2, Serebryanyi A.M.2, Pelevina I.I.2
1 A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia; Moscow, Russia
2 N.N. Semenov Institute of Chemical Physics, Russian Academie of Sciences, Obninsk, Russia; Moscow, Russia
3 N.M. Emanuel Institute of Biochemical Physics, Russian Academie of Sciences, Moscow, Russia
Abstract
Peripheral blood lymphocytes (PBL) of patients with prostate cancer and healthy donors have been investigated using methods of the metaphase chromosome analysis and micronuclei test. Also studies are: a) the influence of tumor cells on the PBL (the study of genomic damage to PBL of the patients), b) the sensitivity to γ-irradiation exposure in vitro (0.05 Gy), c) the influence of blood plasma of the patients with prostate cancer on the healthy donor PBL and d) interaction between donor PBL and PBL of cancer patients (experiments in vitro). It has been shown that sensitivity to the γ-irradiation exposure in vitro (0.05 Gy) of prostate cancer patients' PBL is slightly increased in comparison with that of PBL from healthy donors (the differences are insignificant). Tumor cells in the organism were shown to have an effect on PBL, which results in enhanced chromosome aberration frequencies. Blood plasma of cancer patients causes an increase of chromosome aberrations in the donor blood lymphocytes. This makes it possible to come to the conclusion that tumor cells influence normal PBL and that this phenomenon is similar to a bystander effect.
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