Archives → 2023 → Vol. 63, № 4 → pp. 387–393
Article
On the Relationship of Natural and Modified Radioresistance with Mast Cell Reactivity
I. B. Ushakov1, A. N. Kordenko2
1Burnazyan Federal Medical Biophysical Center of FMBA of Russia, Moscow, Russia 2Voronezh State Pedagogical University, Voronezh, Russia
Abstract
This study was caused by accumulation of the data concerning: 1) relationship between the general reactivity of the body and radioresistance; 2) essential role of mast cells in the formation of radiobiological effects; 3) significant individual features of body radioresistance. Purpose of the study was to identify the relationship of radioresistance indicators with the state of body reactivity, manifested by constitutionally determined features of connective tissue mast cells. Natural radioresistance and modifying effect of hypoxia, hyperoxia and indralin radioprotector were considered. The study was performed on 369 white male rats weighing 215–240 g. To determine the individual characteristics of radioresistance, total and cranio-caudal irradiation of animals was performed. As a hypoxic test, hypoxic gas mixture with 8% oxygen content was used. The criteria of radioresistance were 5- and 30-day survival, weight loss, early transient disability. Index of reactivity of skin mast cells was considered as the diagnostic sign. Relationship features between the level of mast cell reactivity and radioresistance indicators were revealed. It has been shown that the minimum level of natural radioresistance is typical for animals with a high index of mast cell response to hypoxia. The modifying effect of hypoxia during irradiation was manifested in all animals. Also, the highest level of modified radioresistance was observed in rats with average values of the mast cell reactivity index. At the same time, When indralin was used, its radioprotective effect was most pronounced in the group of animals with the maximum reaction of mast cells. The radiomodifying effect of oxygen is mostly expressed in rats with the maximum values of the mast cell reactivity index and is characterized by a decrease in 5-day survival and average life expectancy. The relationship between the characteristics of mast cells and radioresistance can serve as a basis for the development of methods for predicting individual natural and modified radioresistance.
Keywords
Ionizing radiation, radioresistance, radiomodification, hypoxia, hyperoxia, indralin, mast cells, skin
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