Archives → 2021 → V. 61. № 4 → pp. 367-379
Article
Regulation of Gene Activity is One of the Mechanisms of Radiosensitivity Changе
V. F. Mikhailov, L. V. Shulenina
State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
Abstract
The efficient functioning of cells in the body is carried out using intracellular signaling pathways, the activation of which leads to a change in the genome expression profile. Differential activation and repression of genes can cause changes in the radiosensitivity of cells. The effect of radiation on the state of some signaling pathways, as well as microRNA is investigated based on the literature data and the results obtained by us in the experiment. The possibility of changing the radiosensitivity of cells when exposed to signaling pathways that trigger programs of cell death or proliferation is analyzed. Approaches of targeted action on the P53-dependent system of maintaining the genome stability to increase post-radiation survival, as well as the significance of this system in the formation of long-term consequences of radiation exposure, are considered.
Keywords
Radiosensitivity, intracellular signaling pathways, radioprotective compounds, gene expression, P53, microRNA
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