Archives2021V. 61. №2.pp. 117–132

Article

The Methodology of EPR Spectroscopy using in Analysis of Physical and Chemical Mechanisms of Radio-Genetics Damages in Animal and Human Organisms

V. L. Sharygin

N.N. Semyonov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Abstract

The responses of deoxyribonucleotide (dNTP), DNA and protein synthesis systems in blood-forming organs of animals (dogs, mice), as well as the changes in Fe3+-transferrin (Fe3+-TF) and Cu2+-ceruloplasmin (Cu2+-CP) pools in blood due to γ-irradiation and administration of radioprotectors have been studied. It has been shown that changes in Fe3+-TF and Cu2+-CP pools in blood serve the indices of the changes of body radioresistance and are reliably controlled by the EPR technique. The important role in the mechanism of the antiradiation activity of indometophene and indralin belongs to the increased ribonucleotide reductase activity and induction of the ribonucleotide synthesis, which provides effective reparation of the damage to the DNA of the cells in radiosensitive tissues and organs as a result of administration of radioprotectors at the optimal protective doses before radiation exposure.

Keywords

γ-radiation, EPR method, DNA, proteins, deoxyribonucleotides, Fe3+-transferrin, Cu2+-ceruloplasmin, extracellular DNA, radioresistance of organism, radioprotectors

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