Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2021 → V. 61. №1. → pp. 5–13

Article

The Changes in Immunomodulatory and Attractive Properties of Mice Secretions after Radiation Exposure or “Bystander Effect”

B. P. Surinov, A. N. Sharetsky, and N. N. Dukhov

A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Centre Radiology of the Ministry of Health of the Russian Federation, Obninsk, Russia

Abstract

The article analyzes the participation of chemosignaling in between the organisms in the «bystander effect» in groups of animals. The immune reactivity of laboratory mice after exposure to ionizing radiation at doses of 1 or 4 Gy and bystander mice exposed with the volatile components of urine irradiated mice at these doses was studied. It is shown that the ability to antibody forming in bystander mice decreases to a lesser extent than in mice exposed to radiation. The volatile components produced by bystander mice are less attractive for intact recipients and are less immunosuppressives than the volatile components of irradiated mice. The immunostimulatory effect of natural volatile components of intact individuals on mice exposed to direct radiation occurs only at a dose of 1 Gy and is absent at a dose of 4 Gy. In bystander mice, under the influence of natural volatile components of intact mice, regardless of the initial state of immune reactivity, the ability to immune response is about 1.5–1.6 times higher than in intact mice. It was found that the bat components of bystander mice exhibit multidirectional immunomodulatory properties depending on the state of the recipients. They inhibit immune reactivity in intact individuals, but stimulate it in mice irradiated at a dose of 1 Gy. The diversity and role of chemosignaling mechanisms in the development of the bystander effect in the interaction of irradiated and intact animals is discussed. Substantiates the idea of «health effect» mechanisms of chemosignaling in animals.

Keywords

ionizing radiation, mice, natural and postadiation volatile emissions, immunomodulatory properties, chemosignaling in between the organisms, bystander effect, immune reactivity, behavioral responses