Archives2020V. 60. №6.pp. 604–608

Article

Radioprotective Properties of Diserotonin Ester of Succinic Acid under the Condition of Acute and Prolonged γ-60Co Irradiation at Head and Abdominal Shielding

M. V. Vasina,b, R. V. Afanasieva, L. A. Semenovaa, A. A. Galkina

aResearch Testing Center (Aerospace Medicine and Military Ergonomics) of Ministry of Defense of Russian Federation, Moscow, Russia. bRussian Medical Academy of Continuing Professional Education of Ministry of Health of Russian Federation,

Abstract

Experiments on mongrel sex-aged white female rats examined the radioprotective properties of serotonin succinic acid diester under conditions of acute and prolonged γ-irradiation up to 3 hours, including partial head and upper one third of abdomen with lead blocks 3 cm thick. The animals were irradiated on γ 60Co-therapeutic unit at doses of 9 or 8.25 Gy shielding with radiation dose rates of 5 and 24.1 cGy/min, respectively. Succinoyl-5,5'-dihydroxytryptamine or mexamine was administered intraperitoneally at doses of 8 and 15 mg/kg, respectively, prior to irradiation. The radioprotctive efficacy of radioprotectors was assessed by survival rate of rats for 45 days and the average lifespan of dead animals. Acute toxicity of serotonin diester with succinic acid, serotonin m mexamine was determined within 3 days after administration of toxic doses of radioprotectors (0.1–0.4 mmol/l). It was found that under conditions of prolonged γ-irradiation for 3 h succinoyl-5,5'-dihydroxytryptamine in combined application with shielding of head or abdomin shows pronounced radioprotective properties, protecting 80–100% of rats at 40% survival of animals in control group on irradiation. Under the same conditions, serotonin diester, mexamine and head or abdominal shielding did
not have radioprotective effects when separately used. In addition, mexamine was also ineffective when combined with head or abdominal shielding. Under acute irradiation conditions, succinoyl-5,5'-dihydroxytryptamine (8 mg/kg) protected 50% of rats. The acute toxicity of serotonin diester, mexamine and serotonin in
LD50 was consistent with 0.20 (0.19–0.21); 0.28 (0.23–0.34) and 0.27 (0.25–0.29) mmol/l.

Keywords

mexamine, O,O'-succinoyl-5,5'-dihydroxytryptamine, prolonged γ-irradiation, acute γ-irradiation, heat and abdominal shielding

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