Archives → 2020 → V. 60. №4. → pp. 404–410
Article
Experimental Estimation of the Anti-radiation Efficiency of Beta-Estradiol, Indometophene and Composition BP-C2
V. N. Bykova, I. S. Drachevb, A. V. Panchenkoc, E. I. Fedorosc,d, and S. E. Pigarevd
aMoscow Institute of Physics and Technology, Dolgoprudnyi, Russia. bState Scientifiс Research Testing Institute (for Military Medicine), St. Petersburg, Russia. cN.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg, Russia. dMEABCO A/S, Copenhagen, Denmark
Abstract
In experiments on mice, the protective effect of β-estradiol, indometophene, BP-C2 composition in acute radiation exposure was evaluated. We studied 30-day survival, body weight dynamics and condition of hematopoiesis of the irradiated animals. It was established that the studied substances protect the animals from irradiation induced death in the dose range of 4–7 Gy (dose rate 1.1 Gy/min). The values of the dose modification factor were: for the β-estradiol – 1.19; for the indometophene – 1.22; for the BP-C2 – 1.22. The revealed protective effect may be associated with the restoration of bone marrow and with extramedular hematopoiesis, and for the BP-C2 – also with antioxidant activity.
Keywords
ionizing radiation, acute radiation syndrome, radioprotectors, protective action, beta-estradiol, indometophene, composition BP-C2
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