Archives2020V. 60. №4.pp. 396–403

Article

Estimation of Efficiency of Preventive Use of B-190 and Acysol in White Outbred Mice under the Combined Exposure of X-Ray Radiation and Carbon Monoxide

A. V. Zavirsky, V. A. Basharin, V. V. Zatsepin, and P. G. Tolkach

S.M. Kirov Military Medical Academy, St. Petersburg, Russia

Abstract

The article presents data from an experimental study on the effect of carbon monoxide and X-ray radiation on the survival and average lifespan of white male mice. The mice were irradiated in a dose range of
LD30–90/30, then subjected to static inhalation exposure to carbon monoxide. External single exposure was performed on an RUM-17 X-ray unit at a dose rate of 0.32 Gy/min. The radiation doses were 6.5, 7.5 and 8.0 Gy. Static inhalation intoxication with carbon monoxide was carried out at toxicant concentrations of 2100 ppm (0.45 LC50) and 3800 ppm (0.8 LC50), exposure time was 30 min. It was established that preliminary X-ray irradiation in the dose range LD30–90/30 increases the sensitivity of white mice to subsequent exposure to carbon monoxide. The combined effect of ionizing radiation and carbon monoxide led to a decrease in survival and a decrease in the average lifespan of animals in comparison with the isolated effect of these factors. The effectiveness of acyzole and radioprotector B-190 in combined radiation-chemical injury was studied. The use of a radioprotector with a hypoxic mechanism of action before a combined lesion as a result of exposure to X-ray radiation and carbon monoxide aggravates its course, in terms of 30-day survival, hematological parameters. The combined prophylactic use of acyzole and B-190 before combined radiationchemical injury increased the 30-day survival rate of white mice, and improved the hematological parameters of peripheral blood.

Keywords

X-ray radiation, radiation, carbon monoxide, acyzol, B-190, survival, average lifespan

Current Issue

FAQs

What is time from submission of the article to its publication?

The average period from submission to first decision in last year was 30 days, and that from first decision to acceptance was 40 days. The rejection rate for submitted manuscripts in last year was 15%.

Can a manuscript be rejected if it is not prepared in accordance with the rules for preparation of manuscripts?

Yes, in this case the paper can be rejected.

all questions