Archives → 2020 → V. 60. №4. → pp. 378–395
Article
B-190 (Indralin) in the Light of History of Formation of Ideas of the Mechanism of Action of Radioprotectors
M. V. Vasina,b
aScientific Research Test Center of Aerospace Medicine and Military Ergonomics of Ministry of Defence of Russian Federation, Moscow, Russia. bRussian Medical Academy of Continuous Professional Education of the Russian Ministry of Health Care, Moscow, Russia
Abstract
History of discovery of radioprotectors from group of aminothiols and biogenic amines and formation of idea of mechanism of their action is presented. Achievements of domestic scientists. radiation pharmacologists and chemists have been revealed. The role of Institute of Aviation and Space Medicine of Ministry of Defence. Institute of Biophysics of Ministry of Health Care and Mendeleyev Moscow Chemical and Technological Institute in the synthesis and development of radioprotector of emergency action B-190 (indralin) was noted. The mechanism of pharmacological. radioprotective and radiomitigative action of indralin. its advantages over known radioprotectors is presented. Critical role of tissue hypoxia due to increase of oxygen consumption on background of circulatory hypoxia under action of radioprotector α1-adrenomimetic indralin in realization of its radioprotective properties in large animals (dogs and monkeys) is discussed. The role of stimulation of 5H2-serotoninergic receptors in radiomitigative action of indralin is identified.
Keywords
B-190 (indralin). radioprotective effect. circulator hypoxia. tissue hypoxia. radiomitigator. radioprotector. alfa1-adrenoceptors. 5-H2-serotoninergic receptor
Current Issue
FAQs
No, it is impossible to accelerate the publication.
You must send the request to the Russian Academy of Sciences.