Archives → 2020 → V. 60. №4. → pp. 352–361
Article
Experimental Approaches for Preparation and Conduction the Study of the Effects of Radiation to Cognitive Functions of Non-human Primates
I. V. Bondara, L. N. Vasilievaa, L. V. Tereshchenkob, I. D. Shamsieva,b, V. N. Anisimovb, G. V. Mytsinc, and A. V. Latanovb
anstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia bBiological Department, Lomonosov Moscow State University, Moscow, Russia cMedical Technical Complex of the Joint Institute for Nuclear Research, Dubna, Russia
Abstract
Non-human primates are a conventional object for modeling the key components of human operator activity, since they have all the necessary behavioral components characteristic of a human operator performing complex work on the management of external devices. Hand development provides monkeys with the ability to manipulate objects from the outside world. During the evolution of the brain of lower primates, they developed specialized areas in which information about the outside world was processed and eye-hand coordination was carried out. When exposed to extreme environmental factors (for example, ionizing radiation), cognitive processes may suffer in the first place, which will definitely complicate the work of a human operator. Evaluation of critical factors, the severity of the lesion and the course of the recovery process of lost functions is possible in controlled experiments on macaques. This paper describes experimental approaches aimed at (1) preparing an animal for conducting experiments to assess oculomotor activity, (2) ensuring the accumulation of control data on temporal characteristics and accuracy of saccadic eye movements and (3) conducting local irradiation of the brain. All fundamental methodological approaches were tested in real experiments on two animals.
Keywords
non-human primates, cognitive functions, local irradiation of brain tissue, oculomotor activity, assessment of behavior parameters
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