Archives2020V. 60. №4.pp. 341–351

Article

Peripheral Blood Cell Composition in the In-Utero Exposed Techa River Residents

A. V. Vozilovaa, J. R. Akhmadullinaa,b, V. P. Pushkareva, I. V. Krivoschapovaa, and A. V. Akleyeva,b

aUrals Research Center for Radiation Medicine of the Federal Medical-Biological Agency of Russia, Chelyabinsk, Russia. bChelyabinsk State University, Chelyabinsk, Russia

Abstract

The results of the study of the peripheral blood cell composition in the in-utero exposed Techa River residents (Chelyabinsk Oblast), whose exposure began in-utero and continued postnatally, are presented. The study was conducted long time after the onset of radiation exposure (1963–2017). Total in-utero and postnatal exposure doses to red bone marrow (RBM) varied within the range 1–1.905 mGy. The comparison group was composed of persons residing in the same administrative territories but these people were exposed only postnatally. The parameters of erythrocyte, thrombocyte, and leukocyte lineage were studied according to age periodization. Average-group values of peripheral blood parameters both in the groups of in-utero and postnatally exposed persons corresponded with normal values of physiological parameters. The differences of thrombocyte and erythrocyte lineage among exposed persons were mainly noted in the groups of middleaged and old individuals under study. The most changeable happened to be the erythrocyte number, hemoglobin level and colour index of blood. The hemoglobin level was higher in the in-utero exposed men of all ages than that in the comparison group members. When assessing the leukocyte compartment of the peripheral blood in in-utero and postnatally exposed persons, various changes were detected in different cell lineages. Differences from the parameter values in the comparison group members were noted in all cell lineages in the studied men and women of old age. Neutrophil parameters were lower, whereas lymphocyte, monocyte, eosinophil, and basophil parameters were higher than those in the comparison group.

Keywords

in-utero exposed persons, hematopoiesis, bone marrow, leucocytes, lymphocytes, peripheral blood, the Techa River, neutrophils, erythrocytes, thrombocytes

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