Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2020 → V. 60. №3. → pp. 239–248

Article

The Long Noncoding RNA in Radiation Response

L. V. Shulenina^a, V. F. Mikhailov^a, and G. D. Zasukhina^a,b

^aA.I. Burnasyan Federal Medical Biophysical Center of FMBA of Russia, Moscow, Russia ^bVavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

Abstract

The review is devoted to various aspects of studies of the functions of long RNAs (lncRNAs) under radiation exposure. Some hypotheses of the origin of lncRNAs, their functions depending on the cys- or trans-status, and the relationship with other RNA and cell structures are described. The expression of a number of lncRNAs
during a radiation response: MALAT1, HOTAIR, etc., and their possible role in some human pathologies, which can be used both for disease prognosis and as a target for therapy, are examined. Own data made it possible to compare and identify differences in the levels of lncRNA expression (GAS5, RоR, MALAT1, NEAT1, HOTAIR) at low (0.1 Gy) and high (5 Gy) doses of radiation during the formation of an adaptive response in human lymphocytes and lymphoid cells (Jurkat cells).

Keywords

radiation response, long non-coding RNA (lncRNA), low doses of radiation, radiation adaptive response