Archives2020V. 60. № 2.pp. 175–188

Article

Prospects for Inhalation Delivery of Medical Protectors in Radiation Damage

I. M. Ivanov, A. S. Nikiforov, M. A. Yudin, S. V. Chepur, Y. A. Proshina, and A. M. Sventitskaya

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation, St. Peterburg, Russia

Abstract

The possibilities of improving medical protectors for urgent assistance in emergency situations due to inhalational administration of medical preparations are discussed in the article. The advantages of this method of administration have been characterized, the feasibility of using portable dry powder inhalers as a technical means of drug delivery is substantiated. The analysis of literature sources containing information on the inhalation use of drugs from various pharmacological groups has been carried out. Radioprotective agents (cystamine, indraline, naphthyzine), radioprotective agents for prophylactic use (estradiol) means of preventing and arresting the primary reaction to irradiation (ondansetron, metoclopramide, metacin), radio mitigators (analogues of granulocyte colony stimulating factor (G-CSF), growth hormone, betaleukin), as well as incorporated binding agents radionuclides (pentacin) should be considered as the most promising medical preparations for inhalation when exposed to radiation factors. It is stipulated for the presence of effective drugs registered in the Russian Federation and approved for medical use, as well as the technological feasibility of inhalational forms.

Keywords

medical protective equipment, radioprotectors, radiomitigators, primary reaction to radiation, incorporated radionuclides, dry powder inhalers

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