Archives2020V. 60. № 2.pp. 163-174

Article

Danio rerio as an Experimental Model in Radiobiology

A. A. Livanova, A. V. Zavirsky, and V. Yu. Kravtsov

S.M. Kirov Military Medical Academy, Saint-Petersburg, Russia

Abstract

The review is focused on the analysis of published research using Danio rerio embryos, larvae or adult fish as an animal model for radiobiological experiments. Freshwater fish Danio rerio, known in foreign literature as Zebrafish, has already become a world-famous model in developmental biology, molecular and cellular biology, fundamental genetics, and toxicology. Currently, the amount of studies using Danio rerio as a model in both fundamental radiobiological experiments or radioecological monitoring of pollution of aquatic ecosystems is increasing dramatically. In the experiment, both embryos or larvae and adult fish are equally used. At the same time, embryos and larvae are extremely radiosensitive, which makes it possible to study the effects of radiation exposure in small doses, and on the other hand, adult fish are characterized by extreme radioresistance, which determines the prospect of their use for assessing the activity of agents that potentiate the mutagenic effect of ionizing radiation. The set of methodological tools for working with Danio rerio is quite large, and the preference of the researcher is determined by the specific tasks and technical equipment of the laboratory.

Keywords

Danio rerio, zebrafish, radioecological monitoring, bioindication, model organism

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