Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2020 → V. 60. № 1. → pp. 34-41

Article

Genotypic Peculiarity Recovery Post Radiation Violations of the Immune Reactivity in Mice-Females with the Help of Volatile Chemosignals Intact Mice-Males

V. G. Isaevaa and L. Yu. Grivtsova

A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia

Abstract

It is shown that natural volatiles secretion, come in composition urine, of mice males be able to change parameters of immune reactivity mice females reduced after the action of ionizing radiation. In subjected to a single total exposure to ionizing radiation in the sublethal dose (γ-rays 60Co on the installation «Beam-1», dose 1 Gy) females of the CBA line the ability to antibody formation in the spleen on the thymus-dependent antigen (sheep red blood cells) in the early stages (3 days) of the post-radiation period increases only after exposure with secretions of allogeneic males. In the more distant period after ionizing radiation (7 days), the stimulating properties relative to immunogenesis, tested by the content of antibody-forming cells in the spleen, had volatile secretions of both singeneic and allogeneic males. At the same time, the stimulating antibody-Genesis properties of singeneic chemosignals were more pronounced than allogeneic ones. The ability to immune response irradiated (1 Gy) of mice females lines C57Bl6 after exposure with secretions males of syngeneic or allogeneic lines at different times (3 and 7 days) post-radiation period did not change that, evidently, to be associated with low olfactory sensitivity of the mice C57Вl6 line. The role of chemosignals in the electoral stimulation of the immune system in terms of radiation damage are discussed.

Keywords

mice, ionizing radiation, immunoreactivity, genotype, volatile components of secretions