Archives → 2020 → V. 60. № 1. → pp. 12-25
Article
Concept of T-Cell Genus as the Basis for the Analysis of FIsh Results after Local Bone Marrow Exposure
E. I. Tolstykha, A. V. Vozilova, M. O. Degteva and A. V. Akleyeva
Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
Abstract
Evaluation of the frequency of chromosome translocations in peripheral blood T-lymphocytes is a generallyaccepted method of retrospective biodosimetry. Accidental contamination of the Techa River (Chelyabinsk Oblast) in 1950s with bone-seeking long-lived strontium-90 gave an opportunity to evaluate the effect of local red bone marrow (RBM) exposure on translocation formation in the peripheral T-lymphocytes of local inhabitants. The studies of the inhabitants using fluorescent in situ hybridization (FISH) showed that RBM doses calculated based on FISH results were lower than those estimated based on 90Sr body burden measurements. The current study presents analytical review of the published data dealing with the most important processes of the T-lymphocyte development and formation of chromosome aberrations: characteristics of the main compartments where the exposure of T-cell occurs; assessment of the time spent by T-lymphocytes and their progenitors in these compartments; analysis of the dynamics of T-cell populations (proliferation and death); age-related aspects. The paper presents a concept of T-cell Genus (TG) united all the progeny of Tprogenitor with inheritable specific aberrations that could have developed in bone marrow.
Keywords
biodosimetry, T-lymphocytes, chromosomal aberrations, bone marrow, 90Sr, Techa river, T-cell genus
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