Archives → 2019 → Vol. 59, No. 5 → pp. 532-537
Article
Effects of Cranial Exposure to 170 MeV Proton Radiation at a Dose of 5 Gy on the Visual Behavior and Optomotor Response of Adults Rats
Severyukhin Y.S.1,2, Feldman T.B.3,4, Ostrovsky M.А.1,3,4, Molokanov A.G.1
1Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, Russia;Dubna, Russia. 2Department of Biophysics, Faculty of Natural and Engineering Sciences, Dubna State University, Dubna, Russia;Dubna, Russia. 3 Department of Molecular Physiology, Faculty of Biology, Moscow State University, Moscow, Russia;Moscow, Russia. 4 N.M. Emanuel Institute of Biochemical Physic, RAS, Moscow, Russia;Moscow, Russia.
Abstract
In this experiment, the optomotor reflex and visual behavior were evaluated in the rats exposed to protons at a dose of 5 Gy. To evaluate the visual function, the equipment including a platform and a display with visual stimulation was used. Some behavioral changes induced in rats under cranial irradiation with 170 MeV protons have been detected. The cranial effect of protons on animals did not lead to a statistically significant decrease in the opto-motor response (the ratio of correct and incorrect head turns) in the rats on days 30 and 90 after irradiation. However, in the remote period after irradiation, statistically significant changes in the visual behavior of irradiated animals were detected. It has been established that the total time of the animal’s head in the area where it is able to focus on the visual stimulus is decreased in the irradiated animals by the 90-th day after irradiation.
Keywords
rats, optomotor response, vision, behavioral responses, protons
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