Archives → 2019 → Vol. 59, No. 5 → pp. 488-502
Article
The Use of Radioprotective Agents to Prevent the Effects Associated with Aging
Bykov V.N.1, Grebenyuk A.N.2, Ushakov I.B.3
1Moscow Institute of Physics and Technology National Research University, Dolgoprudny, Russia 2Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia 3 State Research Center − Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
Abstract
Anti-aging properties can be found in a lot of compounds with radiation-protective effects. Among such compounds are: bioflavonoids, some antioxidants (N-acetylcysteine), melatonin, some non-steroid anti-inflammatory agents and statins, angiotensin converting enzyme inhibitors, metformin, rapamycin etc. The effects of the drugs can develop both with their long-term use and with a single application against the background of acute exposure to ionizing radiation at lethal doses. At the same time, there has been no evidence of anti-aging properties of «classical» radiation-protective agents such as cystamine, amifostine, adrenergic alfa-blockers and androgenic drugs. This could be linked to their high toxicity, especially after a prolonged use. However, until now there has been no complete comparison of the exerted effects, contributing to the radiation-protective and anti-aging protective properties.
Keywords
anti-radiation agents, anti-aging effects, radioprotector, geroprotector, increase in life expectancy
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