Archives → 2019 → Vol. 59, No. 4 → pp. 388-393
Article
Antimutagenic Effect of Anti-Radiation Drugs in an Experiment on Mice
Sycheva L.P., Lisina N.I., Shchegoleva R.A., Rozhdestvensky L.M.
State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
Abstract
Antimutagenic effect of three anti-radiation drugs: betaleukin, indralin and riboxin was studied on the model of acute R-irradiation of mice, using a micronucleus test on polychromatic erythrocytes (MN-PСE) of bone marrow. The drugs were administered respectively for 2 h, 10 and 30 min before the start of irradiation at a dose of 1 Gy. All drugs decreased a mutagenic effect 24 h after irradiation, but the antimutagenic effect of riboxin was not statistically significant. The Dose Reduction Factor (DRF) for the MN-PCE index for betaleukin, indralin and riboxin was 2.5, 1.9 and 1.4 (present study) and was significantly higher than DRF for a 30-day survival (literature data). Thus, the antimutagenic effect of the three drugs has been revealed. These data are important for understanding the mechanism of their protective action. An applied approach can be useful for screening new anti-radiation drugs.
Keywords
X-rays, micronuclei, betaleukin, indralin, riboxin, polychromatophilic erythrocytes of bone marrow, x-rays, micronuclei, betaleukin, enderlin, riboxin, polychromatic erythrocytes of the bone marrow
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