Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2019 → Vol. 59, No. 2 → pp. 200-204

Article

NOS Inhibitors as Agents for Prevention and Therapy of Combined Radiation-Thermal Injuries

Chesnakova E.A., Filimonova M.V., Makarchuk V.M., Samsonovа A.S., Коrneeva T.S., Shevchenko L.I., Surinova V.I., Filimonov A.S.

A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia

Abstract

A high efficiency of NOS inhibitors T1004 and T1023 is shown when they are used at low-toxic doses (1/8–1/12 LD16) on the model of a combined radiation-thermal injury (CRTI) by the criterion of 30-day survival of animals. CRTI included total body γ-irradiation at a dose of 7 Gy and then III B degree thermal burn of 10% body surface with the aid of powerful flash light. The use of T1004 5 min or 4 h after CRTI showed a statistically significant increase of the survival rate of animals up to 90–100%; life expectancy in the control group was 10.9 ± 5.6 days. The multiple (every 4 hours, on days 2, 5, 6) application of T1004 or T1023 after CRTI was accompanied by an increase in the survival of the experimental animals by 40%, whereas the survival rate was 20% in the control. Life expectancy in the control group did not differ statistically significantly with the group treated with Т1004 and it was 12.5 ± 9.5 days and 12.7 ± 7.4 days, whereas we observed the tendency to the increased life expectancy in the group treated with T1023: as compared to the control group it was 18.2 ± 6.9 days.

Keywords

Combined radiation-thermal injuries, NOS inhibitors, survival, treatment, death rate, life expectancy, Micе