Archives2019Vol. 59, No. 2pp. 183-190

Article

Ethanol as a Possible Modifier of Acute Radiation Lesions of the Brain

Fyodorov V.P.1, Ushakov I.B.1,2, Shalnova G.A.1

1Russian State Research Center − Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia 2Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, Saint-Petersburg, Russia

Abstract

Cerebral effects were studied in the experiments on rats exposed to acute γ-radiation of the head at cerebral doses with previous or subsequent administration of different ethanol doses. It is shown that both factors cause similar changes in the neurological symptoms and neuromorphological effects. Ethanol before irradiation did not significantly modify the state of neurons. but caused the appearance of synapses degenerating by a filamental type. After irradiation. ethanol at the threshold dose did not change. and at a large tranquilizing dose slightly increased radiation changes in neurons and synapses. The effects of radiomodification depended on the dose of ethanol and the time of its administration.

Keywords

Irradiation, ethanol, brain, neurons, synapses combined effect of ethanol and -irradiation

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