Archives → 2019 → Vol. 59, No. 2 → pp. 161-169
Article
Radiomitigators – Classification, Pharmacological Properties and Application Prospects
Legeza V.I.1, Grebenyuk A.N.2, Drachev I.S.1
1State Scientific Research Test Institute of the Military Medicine, St. Petersburg, Russia 2Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia
Abstract
Classification of radiomitigators – antiradiation agents for prevention or reduction of the severity of clinical manifestations of the acute radiation syndrome and its delayed and long-term consequences is proposed. In the proposed classification, radiomitigators used for prophylaxis and treatment of the immediate and remote clinical manifestations of the acute radiation syndrome are divided into the following main groups: means (drugs) for treatment of the bone marrow syndrome; means for treatment of the gastrointestinal syndrome; means for treatment of local and subtotal manifestations of radiation injuries; means for prevention and treatment of the delayed and long-term effects of irradiation. The list and brief characteristics of the most promi-sing radiomitigators from the groups of cytokines, growth factors, antioxidants, immunomodulators, steroid hormone analogs, and apoptosis blockers are given.
Keywords
Ionizing radiation, acute radiation syndrome, radiation syndromes, delayed and long-term effects of irradiation, radiomitigators, classification, pharmacological properties
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