Archives → 2019 → Vol. 59, No. 2 → pp. 150-160
Article
Pharmacological Protection in Distant Space: Modern View
Ushakov I.B.1,2, Vasin M.V.3
1A.I. Burnazyan Federal Medical Biophysical Center of Federal Biomediсal Agency, St. Petersburg, Russia 2A.M. Nikiforov All-Russian Center of the Emergency and Radiation Medicine of Ministry of Emergency Situation of Russia, St. Petersburg, Russia 3Russian Medical Academy of Continuous Professional Education of Russian Ministry of Health, Moscow, Russia
Abstract
Radiation situation for astronauts at long space flights is caused by the impact on the spaceship of low-intensive radiation of galactic and solar space beams. There is a small probability of a high solar activity during long space flights, which can threaten astronauts by exposure at the doses causing the determined effects of radiation. B-190 (indralin) is the most perspective radioprotector from a small number of other radioprotective drugs allowed for use in humans. Antiemetic Latran (ondansetron) is of interest for prophylaxis and stopping the primary radiation reaction. Use of radiomitigators in the conditions proton radiation from the increased solar activity allows acceleration of post-radiation recovery processes in the hematopoietic tissue. Neupomax is offered as pathogenetic therapy of acute radiation illness. Natural antioxidants, drugs and nutritional supplements as radiomodulators, good qualitative nutrition including vegetable products enriched with flavonoids and vitamins C, E and carotin potentially promote prevention of reduced biological age of astronauts at long flights under the influence of solar and galactic space beams and stress factors of a space flight.
Keywords
Solar space, manned space flight, radioprotective agents, indralin, Latran (ondansetron), neipomax(filgrastim), natural antioxidants
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