Archives → 2019 → Vol. 59, No. 1 → pp. 58-62
Article
Experimental Justification of Approaches to Development of Pathogenetic Meansof Prevention and Treatment of Early Postradiation Gastrointestinal Disorders
Drachev I.S.1, Legeza V.I.2, Seleznev A.B.1, Grebenyuk A.N.2
1State Scientific Research Test Institute of the military medicine, St. Petersburg, Russia 2Military Medical Academy, St. Petersburg, Russia
Abstract
Experiments on dogs have shown that antagonists of D2 (domperidone, metoclopramide, dimetpramid), 5-HT3 (ondansetron, palonosetron) and NK1-receptor (aprepitant) impair gastrointestinal manifestations of the primary reaction to irradiation (vomiting and diarrhea). H2 blockers (cimetidine) and opiate receptors (naloxone), inhibitors of the synthesis of prostaglandins (voltaren, indomethacin), M-holinolitik methacin have a predominantly antidiarrheal effect. None of the tested drugs reduce the severity of early postradiation hypokinesia. It is assumed that the most promising direction of increasing the effectiveness of prevention and treatment of the main clinical manifestations of the primary reaction to irradiation is the development of combined drugs that affect various links of its pathogenesis.
Keywords
Ionizing radiation, irradiation, primary reaction to irradiation, gastrointestinal syndrome, nausea, vomiting, diarrhea, antiemetics, antidiarrheal agents
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