Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2019 → Vol. 59, No. 3 → pp. 274-278

Article

Evaluation of Antiradiation Efficiency of Flagellin in Experiments on Mice

Lisina N.I.¹, Shchegoleva R.A.¹, Shlyakova T.G.¹, Zorin V.V.¹, Shkayev A.E.², Rozhdestvensky L.M.¹

¹ Burnazyan Federal Medical Biophysical Center of FMBA, Moscow, Russia ² Institute of Veterinary Virology and Microbiology, Pokrov, Russia

Abstract

In the experiments on SPF mice, the authors evaluated the radio-protective efficiency of the recombinant Flagellin, developed at the Institute of High-Purity Preparations (St. Petersburg), administered at a wide range of doses of 0.004–2 mg/kg for 30 min prior to X-ray irradiation in the dose range of 7–10 Gy. The effectiveness of Flagellin was evaluated in terms of 30-day survival rates of the mice, the average life expectancy and according to the DMF criterion for bone marrow death. The DMF values were 1.24–1.23–1.22 at the level of LD₁₆, LD₅₀ and LD₈₄. ED₅₀ approximately equals to 25 mkg/kg. The dose-response effect of Flagellin was evaluated to reach the plateau at a dose of 0.2 mg/kg.

Keywords

anti-radiation drugs, flagellin, r-radiation, mice SPF category, radioprotective efficiency