Archives → 2019 → Vol. 59, No. 3 → pp. 261-273
Article
The “Radiation-Induced Non-Targeted Effects” and their Role in Human Cell Response to Low Radiation Forcing
Pelevina I.I.1, Petushkova V.V.1, Biryukov V.А.2, Akleyev A.V.3,4, Neifakh Е.А.1, Minaeva N.G.2, Ktitorova О.V.1, Aleshchenko А.V.1,5, Pleshakova R.I.1
1 N.N. Semenov Institute of Chemical Physics of Russian Academy of Sciences, Moscow, Russia 2 A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia 3 Urals Research Center of Radiation Medicine, Chelyabinsk, Russia 4 Chelyabinsk State University, Chelyabinsk, Russia 5 N.M. Emmanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russia
Abstract
«Radiation-induced non-targeted effects» are the ability of the radiation-induced changes to transfer from irradiated cells to non-irradiated ones. The article presents a brief review of the Russian research in this field for the period of 1985–2018, dedicated to manifestations of «non-targeted effects» as a human cell response to low radiation forcing under different conditions. Initial investigations are related to the zone of the Chernobyl disaster, and were held in the first years after the accident, the recent ones are the result of studying modern radiotherapy problems and the issues related to chronic irradiation of the population of the Chelyabinsk region. The review reflects the new data received by our team related to the radiation-induced «bystander effect» and adaptive response.
Keywords
radiation-induced "bystander effect", in adaptive response, radiosensitivity, the disaster at chernobyl, brachytherapy, chronic irradiation, lymphocytes of peripheral human blood
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