Archives2019Vol. 59, No. 6pp. 599-609

Article

Evaluation of Radiomodifying Effect of Creatine on Survival, Liver Creatine-Creatine Kinase System, Hepatocytes Nucleus-Nucleolar Apparatus and Peripheral Blood Cells of Rats

L.S. Nersesova, M.S. Petrosyan, E.M. Karalova, A.S. Avetisyan, L.O. Abroyan, L.A. Akopian, Z.A. Karalyan, J.I. Akopian

Institute of Molecular Biology of NAS RA, Yerevan, Armenia

Abstract

Creatine kinase (CK), along with his substrates creatine (Cr) and creatine phosphate (CrP) forms the Cr-CrP-CK system, which, as part of the cell energy metabolism, retains the stability of mitochondrial membranes, in addition to its buffer and transport roles that altogether serve as the basis for the overall protection the system holds against the oxidative stress. Considering that the basis of the mechanism for X-ray irradiation on a cell is the oxidative stress, the purpose of this research was to evaluate the radio-modifying effect of Cr on rat survival, the population composition of the peripheral blood cells and hepatocytes, as well as the CK activity and Cr content in liver, all in the case of a single irradiation amounting to 6.5 Gy. Creatine solution at a dose of 1 g / kg in 0.9% glucose, used per os 2 weeks before and then after irradiation, has a significant protective effect on the parameters studied, and thus, creatine can be considered as a potential radio-protector.

Keywords

X-Ray exposure, creatine, creatine kinase, survival model, population composition of peripheral blood cells, hepatocytes, rats, radioprotection

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