Radiation biology. Radioecology
ISSN: 0869-8031

Archives → 2019 → Vol. 59, No. 6 → pp. 585-591

Article

Evaluation Efficiency of Different antiradiation Preparations Accrding to Phosphorylated Hyston H2AX and Micro-nucleus Test

M.A. Ignatov1, T.M. Blokhina1,2, L.P. Sycheva1,2, N.U. Vorobyeva1, A.N. Osipov1,2, L.M. Rozhdestvensky1

1 State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia. 2 FSBI – N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.

Abstract

In experiments at R-irradiated female F1 mice (CBA×C57Bl), the possibility of using rapid tests for the number of double-stranded DNA breaks (γH2AX) in the spleen and micronuclei in polychromatophilic erythrocytes (MN-PCE) of the bone marrow for an approximate evaluation of the effectiveness of antiradiation agents was investigated. Cytokine betaleukin, α-adrenomimetic indralin and nucleoside riboxin were tested. By the DCF criterion, γH2AX showed a higher sensitivity compared to MN-PCE. Between the two indicators, a significant degree of correlation was revealed.

Keywords

γH2AX, micronucleus test, X-ray, betaleykin, indralin, riboxin

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