Archives → 2018 → Vol. 58, No. 2 → pp. 157-165
Article
Peculiarities of Dynamics of Peripheral Blood Cell Composition in Exposed Individuals in the Period Prior to Chronic Myeloleukemia Development
Akleyev A.A.1 2
1 South- Ural State Medical University, Chelyabinsk, Russia 2 Urals Research Centerfor Radiation Medicine (URCRM), Chelyabinsk, Russia
Abstract
A retrospective analysis of the peripheral blood cell composition had been performed among 21 chronically accidentally exposed residents of the Techa River settlements (average exposure dose of the red bone marrow was 0.71 ± 0.12 Gy), who were later diagnosed with chronic myeloleukemia. Prior to the development of leukemia an increase in the number of neutrophil granulocytes in comparison with the exposed to similar doses individuals without leukemia had been registered for many years. A more significant increase in the number of neutrophils regarding the reference group was noted during the hemopoiesis recovery period following a decrease of the exposure dose rate of RBM (1957-1970). During the CML latency period an average value of a relative number of neutrophils in the blood against the background of relative lymphocytopenia remained higher than in the reference group.
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