Archives → 2018 → Vol. 58, No. 2 → pp. 126-145
Article
Modification of Radiocerebral Effects by Мodified Gas Medium
Ushakov I.B.1, Fyodorov V.P.1
1 A.I. Burnazyan Federal Medical and Biophysical Center, Moscow, Russia
Abstract
The review presents the literary and proprietary data on the modification of the altered gas medium of the radiation damage to the brain. Hypoxia increases, and oxygen reduces the reserve time of manifestation of cerebral effects. A similar pattern is revealed for all studied doses, and also for hypoxia before exposure. Under the influence of hypoxia following irradiation, the observed effects depended on the radiation dose. Irradiation in oxygen reduces the reserve time of development of cerebral effects and intensifies the severity of pathological changes in neurons, but brain edema is formed later. The action of oxygen before irradiation did not modify, and after irradiation intensified the damage to the brain. Radiomodification effects are more pronounced in rats than in dogs, and in general irradiation at a dose of 5 Gy HGS-7 and GGS-10 did not generally modify cerebral effects in dogs. At the same time, neurologic symptoms were even worse in a number of indices. Thus, the analysis of the available data has shown the ambiguity of the effect of the altered gas environment on radiocerebral effects, which requires further research.
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